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The modern methods of stem cells and bioengineering technologies application in regenerative medicine


Work number - P 2 AWARDED

Presented State Institute of Genetic and Regenerative Medicine of the National Academy of Medical Sciences of Ukraine

Authors:
Gabriyelyan A. V., Holyuk Ye. L., Dombrovs'kyǐ D. B., Kyryk V. М., Medvediev V. V., Rudenko S. A., Shablii V. A.

The scientific value and practical significance of the study is based on improving the safety and effectiveness of the treatment of the cardiovascular, nervous and musculoskeletal system diseases by developing and implementing the modern methods of stem cells therapy and bioengineering technologies. For the first time, the neuroprotective effect of the transplantation of fetal neural progenitors was demonstrated, as well as their ability to migrate to the ischemized hippocampus, to differentiate into neurons and form synaptic contacts with recipient cells. First time ever, the opposite effect of fetal cerebellar and olfactory bulb transplantation on spasticity and pain in spinal cord injury and recovery of cerebellar function was revealed. The markers of highly proliferative population of multipotent cells from human placenta have been determined for the first time. The concept of criteria for safety and quality of cellular transplants for preclinical and clinical studies was formulated. For the first time in the world, clinical studies have shown positive results in patients with ischemic cardiomyopathy who underwent intramyocardial administration of placental multipotent stromal cells. For the first time, the technology of complex correction of heart functions with the use of umbilical cord blood stem cells in patients with chronic heart failure awaiting heart transplantation has been developed. The concept of providing medical care using cell technology to patients with critical limb ischemia has been formulated. For the first time, biotechnological approaches to the treatment of osteoarthritis and aseptic necrosis of joints have been developed using regenerative injection therapy techniques, as well as the replacement of bone defects with a combination of bone scaffolds and biotechnological products. The translation into the clinic of high-tech approaches to cell and tissue therapy in more than 1,000 patients has increased the efficiency of providing highly specialized medical care to the population, as well as reduced disability and mortality rates, which are of significant social importance. Economic effect is more than 260 million UAH.

Number of publications: 6 monographs (1 abroad), 1 textbook, 188 articles (88 – in English, 21 – with impact factor). The total number of references to the authors' publications/h-index of the study, according to the databases is respectively: Web of Science – 43/4, Scopus – 57/4, Google Scholar – 557/11. 40 patents of Ukraine and 7 innovations were received.

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