Diagnosis and treatment of chronic non-viral liver disease

Work number - P 24 ALLOWED TO PARTICIPATE

Authors:

Mytnik Z.M., Kharchenko N.V.,  Gubskyi Y. I., Virstyuk N.G., Zaharash A.D., Nejko V.E., Deltsova  O. I., Erstenyuk G.M., Мoyseyenko  N. I., Kryzanivska A.Y.

Statemost superior educational facility

"TheIvano-FrankivskNationalMedicalUniversity"

This work belongs to an important section of medicine - hepatology. The aim of the work was to improve the efficiency of treatment of patients with chronic nonviral liver disease based on exploring new pathogenetic links of diseases as well as to develop and implement effective diagnostic, prognostic and therapeutic technologies using domestic drugs.

The authors have established a new concept for the development and progression of chronic (alcoholic, toxic, drug-induced, autoimmune and metabolic) hepatitis and cirrhosis of the liver. The frequency and pathogenetic links of liver damage in long-term employees of enterprises located in Prykarpattya have been determined. Procedures of examination, treatment and preventive measures have been developed and tested. New mechanisms of toxic effects of chemicals, medication, ionizing radiation, herbicides and heavy metals on the structure of hepatocytes and hepatic lipid composition changes have been experimentally identified. Molecular mechanisms of necrotic and apoptotic cell death during toxic damage of DNA were proven. For the first time antioxidant, hepatoprotective and cytoprotective activity of a number of domestic drugs and new physiologically active compounds have been established.

New medical technologies using domestic drugs have been implemented in the work of medical diagnostic-preventivecenters of Ukraine, thereby increasing the efficiency of treatment and preventing recurrence of complications, liver cirrhosis, liver failure and hepatocellular carcinoma. This implementation leads to reduction of disability terms, frequency of disability and mortality. Moreover, used technologies are effective, safe and accessible to the broad population, that brings economic benefits.

This work resulted in 728 scientific papers, including 46 in international journals, 356 articles in professional journals, 67 certificates for invention and utility model, 9 monographs, 15 guidelines and information sheets. The results of the work are highlighted in 20 textbooks and manuals. This work was based on the results of  29 theseses, including 15 doctoral and 14 candidate of medical sciences theseses.