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Synthesis, characterization of metal-containing macrocyclic complexes

Work number - M 36 AWARDED

Presented Institute of General and Inorganic Chemistry of V.I. Vernadsky NAS of Ukraine.

Selin R.O., Ph.D. Chernii S.V., Shtokvysh O.O

We present the synthesis and characterization of a series of metal-containing macrocyclic complexes, including asymmetric iron (II) clathrochelates with ion-receptor and fluorescent groups and 3d metals complexes with β-dicarbonyl ligands. Metal-promoted С-С bond formation reactions have been originally performed for the dioximate positions of clathrochelates under the conditions of the Sonogashiro reaction.

For the first time, copper-promoted reactions of the terminal ethynyl group with organic azides were used for asymmetrical modification of iron (II) clathrochelates via a triazole linker. For once, iron (II) clathrochelates have been modified by ion-receptor groups, which make them capable of selective binding and cation detection. The iron (II) clathrochelates functionalized with terminal reactive ethynyl groups were also synthesized. Obtained iron (II) clathrochelate complexes are unique and have no analogs in Ukraine and the world.

We propose highly effective agents among metal-containing macrocyclic iron (II) clathrochelates and phthalocyanine complexes against pathological amyloid protein aggregation. These compounds significantly inhibit the process of amyloid aggregation, have low values of effective inhibitor concentration and alter the morphology of the protein aggregates formed in their presence. Proposed anti-amyloidogenic agents have characteristics that make them stand out among many foreign analogs. Correlation between structure and anti-fibrillogenic properties of metal-containing macrocyclic complexes was established. The formation of complexes of macrocyclic compounds with mature fibrils has been shown.

Number of publications: 32 publications, notably 11 articles (5 of which were published in foreign English-language journals with impact factor), 21 abstracts of congresses and conferences. The total number of links to author publications / h-index of work, according to the databases, is respectively: Web of Science - 17/3, Scopus - 25/3, Google Scholar - 30/3.