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Dysfunction of the ion channels: from molecular mechanisms to novel strategies of treatment


Work number - M 32 FILED

Presented O.O. Bogomoletz Institute of Physiology, NAS Ukraine

Authors:
1. DRYN Dariia - Ph.D., Researcher, Department of Cellular Membranology, O.O. Bogomoletz Institute of Physiology, NAS of Ukraine. 2. MELNYK Mariia - Ph.D., Researcher, Department of Cellular Membranology, O.O. Bogomoletz Institute of Physiology, NAS of Ukraine. 3. HALAIDYCH Oleh - Ph.D., Junior Researcher, Department of Sensory Signaling, O.O. Bogomoletz Institute of Physiology, NAS of Ukraine.

The studies revealed functional expression, biophysical properties, and regulatory role of TRP and BKCa channels, which are widely expressed in smooth muscles. Our findings showed the role of these ion channels in the development of visceral and vascular smooth muscle dysfunctions, the immune system, skin, respiratory diseases, diabetic and chronic hypoxic pulmonary hypertension, and others.

It was shown the regulatory role of TRPC4-, TRPV4-, TRPV1-, TRPA1- and BKCa channels in the smooth muscle is determining factor in such pathologies. In inflammatory processes after chemotherapy, intestinal macrophages expressing TRPV4 channels contribute to intestinal hyperactivity and may be potential targets for this problem correction. General anesthesia significantly supressed intestinal motility and it has been found that inhibition of TRPC4 channels is involved in this. It has been shown that TRPA1 and TRPV1 channels are contributed in the mechanism of inflammation under an allergic contact dermatitis. Diabetes increased the activity of BKCa channels and reversed hypoxic vasoconstriction reaction in the pulmonary arteries. The pharmacological modulators of the described ion channels were investigated: C60 fullerenes that selectively suppressed TRPC4- and BKCa channels, plasmonic gold nanoparticles and encapsulated quercetin liposomes as activators of BKCa channels.

Smooth muscle cells differentiated from stem cell culture making them a promising model for the study of various ion channel dysfunctions and to test new pharmacotherapeutic agents.

Number of publications: 38, 22 articles (17 - in English-language journals with impact factor), 16 abstracts. The total number of references to authors' publications / h-index of work, according to the databases is respectively: Web of Science - 47/6, Scopus – 51/7, Google Shcolar –78 / 9. 1 patent of Ukraine for invention.

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