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Microbiome correction and personalized rehabilitation in war and peacetime


Presented Institute of Microbiology and Virology. D.K. Zabolotny NAS of Ukraine

Safronova L.A., Fomina M.O., Kryvtsova M.V., Garmasheva I.L., Babenko L.P., Bubnov R.V., Bila V.V., Demchenko O.M.

The aim of the work was to study the role of the microbiome in the development of various diseases and to develop modern methods of its correction for personalized treatment and rehabilitation of patients in war and peacetime.

Based on probiotic strains of microorganisms of different taxonomic groups, which have a wide spectrum of biological activity and meet international requirements, a number of microbial preparations have been developed. It was created a unique collection of cultures of lactic acid bacteria and Saccharomycetaceae yeasts, isolated from traditional fermented products and gastrointestinal tract of healthy long-lived people, which was used for the development of microbial preparations for fermented foods with increased functional properties.

The effectiveness and safety of the proposed microbial preparations in the complex personalized treatment and prevention of various diseases, such as chronic hepatitis, obstructive pulmonary disease, infectious and inflammatory diseases of the urogenital tract, inflammatory periodontal diseases, metabolic disorders, in particular diabetes and obesity, etc., were proven on original experimental models and in clinical practice. A wide range of microbiota-associated markers have been developed to stratify patients based on phenotypic data, which is the basis of personalized treatment of various diseases.

Personalized probiotic therapy has been implemented in various medical scenarios, where the military rehabilitation process is an important component. A holistic concept of "Personalized rehabilitation of wounded soldiers at different stages" is proposed, which covers physical, psychological and biological aspects. A comprehensive military rehabilitation strategy includes the use of probiotics in combination with neuromuscular rehabilitation based on precision interventions. This approach to personalized rehabilitation combines innovative methods, such as targeted ultrasound-guided interventions and individualized probiotic therapy, which can significantly contribute to the recovery and improvement of the quality of life of military personnel.

Number of publications: umber of publications on the work: 13 collective monographs, including 12 in foreign publications; articles in journals – 168, including 121 in category "A" journals (44 of them in foreign publications), and 47 articles in journals included in category "B". The total number of citations to the authors' publications/h-index for the work according to the databases is, respectively, Web of Science: 1151/47, Scopus: 1609/79, Google Scholar: 2653/101.