You are here

Changes in local potentials of exciting tissues and behavioral reactions in normal and pathology


Work number - M 65 ALLOWED TO PARTICIPATE

Presented O.O. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine

Authors:
1. FEDORIUK Mykhailo, Candidate of Biological Sciences, Junior Researcher of the Department of Physical and Chemical Biology of Cell Membranes, Bogomoletz Institute of Physiology.
2. BOHOVYK Ruslan, Candidate of Biological Sciences, Junior Researcher of the Department of Physical and Chemical Biology of Cell Membranes, Bogomoletz Institute of Physiology.
3. STEFANENKO Maria, PHD student of the Department of Physical and Chemical Biology of Cell Membranes, Bogomoletz Institute of Physiology.

The authors present the results of studies to determine the effect of protease-activated receptors type 1 (PAR1) on changes in local potentials in the hippocampus during the development of status epilepticus and behavioral responses during the latent and chronic period of epilepsy in adult rats. The role of acid sensing ion channels (ASICs) in the electrical activity of the hippocampus and the behavior of rats in an experimental model of epilepsy was determined. Preliminary data on the effect of ASICs on the behavior of rats with an LPS model of Parkinson's disease were obtained. A method of vibrodissociation has been developed to isolate certain segments of the nephron from human and rodent kidneys. The progression of diabetic kidney disease in rats was visualized using scanning ion microscopy.

The authors found that interictal bursts of neuronal activity, which are associated with the onset of an epileptic seizure, occurred earlier in the olfactory bulb than in the hippocampus and amygdala, and were much greater in intensity. Blocking of PAR1 receptors led to a decrease in the power of theta and gamma rhythms during the transit phase of status epilepticus, normalized the level of anxiety and emotional memory. It was found that the blockade of ASICs has a marked antiepileptic effect, reduces the maximum frequency of epileptiform phenomena in the hippocampus in modeling Parkinson's disease, reduces the dominant frequency of theta rhythm and the overall level of locomotor activity, helps to normalize anxiety and normalization.

Number of publications: 17 articles ( 9 of them in international journals) , 21 abstracts at international conferences and 2 patents. The total number of references to the authors' publications / h-index of the work, according to the databases is respectively: SCOPUS - 27/4, Google Scholar 62/4,Web of Science 28/4.

Comments