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Pathogenesis and new technologies for diagnosis and treatment of the most common diseases of the digestive system

Work number - M 64 AWARDED

Author's:Prybytko I.Yu., Beregovyi S.M., Kobyliak N.,M., Antonenko A.V .

Presented ESC "Institute of Biology," Taras Shevchenko National University of Kyiv.

The cycle of scientific works consists of 52 articles and 75 abstracts of conferences, published within 5 years. In animal experiments were investigated the molecular and biochemical mechanisms of gastric ulcers formations caused by stress, nonsteroidal anti-inflammatory drugs and ethanol. This study has been optimized treatment forgastropathy caused by nonsteroidal anti-inflammatory drugs in osteoarthritis patients, leading to a reduction of hospitalization for 2-3 days. Thus providing significant economic impact on health care in our country.

Additional to standard gastropathy treatment regimen with proton pump inhibitors administration of multiprobioticeliminates dysbiosis caused by nonsteroidal anti-inflammatory drugs and decrease healing of erosive ulcers of the gastric mucosa. A number of fundamental results were received for the development of nonalcoholic fatty liver disease in rats induced by  high-calorie diet  and  monosodium glutamate.

          We assess diagnostic accuracy of a new US method – shear wave elastography and estimate comparative effectiveness as compared with other qualitative and quantitative US methods for nonsteroidal anti-inflammatory drugs diagnosis in patients with type 2 diabetes and in laboratory animals with experimental obesity. Proven effectiveness of probiotics in patients with different stages of nonalcoholic fatty liver disease and diabetes mellitus type 2 as an adjunct to the standard treatment regimen to correct a chronic systemic inflammatory response.

 Results of cycle of scientific work is an example of the implementation of basic research into clinical practice and may be used in therapies, gastrointestinal, neurological and cardiology departments to improve the diagnosis and treatment of some of the most common diseases of the digestive system - gastric ulcer and nonalcoholic fatty liver disease in patients with diabetes mellitus type 2.

Results of research on the topic described in 52 scientific articles (including 14 in foreign journals), 75 theses. The works of authors cited in 16 scientific articles, h-index = 3. General number of authors publications: 52 scientific articles 75 theses.