Work number - P 17 FILED
StoikaR.S., ZaichenkoO.S., LukyanovaN.Yu., MatyshevskaO.P., PrylutskyYu.I., PanchukR.R., AbramovM.V., PyrkoYa.V.
Theseries of works ispresentedforcompetitiononStateawardofUkrainein the field of science and technology
Themaingoalsofa seriesofworks: 1) presentbasicprinciplesofcreationofnovelmultifunctionalnanomaterials; 2) briefly describe the ways of synthesis of these materials with the polymeric (оrganic) оr mineral basis; 3) estimate the bio-аndеco-safety of their usage;4) demonstrate an effectiveness of their applicationin biology and medicine.
The authors created and characterized novel native multifunctional nanomaterials of different types: 1) functional surface active oligomers and polymers and supramolecular nanostructures on their basis for delivery of anticancer drugs or DNA; 2) Nanocomplexes of C60 Fulleren C60 with immobilized drugs and fullerene nanotubes; 3) ferromagnetic nanoparticles with immobilized anticancer drugs and ferromagnetic microparticles with the immobilized antibodies for fractionation of tumor cells or isolation of specific protein molecules based on their affinity to the antibodies; 4) metallic nanoparticles of gold, silver, as well as the bi-metallic (Ag/Au) nanoparticles. The presented series of works covers both the molecular design and synthesis of these nanomaterials, as well as their application the medicinal preparations. Eco-safety characteristics of the polymeric metal-containing nanomaterials have been also examined.
The results of series of works have a significance for both the fundamental biology and medicine, as well as for clinics, particularly the oncology, traumatology and cardiology. It was shown that the created nanomaterials enhance the efficiency of action of medicines due to a decrease of acting dose of drugs with preserving their equal treatment effect. They also allow decreasing negative side effect of anticancer drugs in the organism. It was demonstrated that drugs immobilized on the created nanocarriers are capable of more rapid, than free forms of drugs, penetration into targeted cells and of preservation of their physico-chemical and biological properties. It was shown that the drugs incorporated into the created nanocomplexes act more efficiently towards tumor cells with the multidrug resistance.
The results of a series of works were presentedin264 articles,including 201articles in journals of SCOPUS basis with total impact-factor 300.26and citation number - 2112. H-іndex of all authors equals69. These results were also included 38 patents of Ukraine, including 20 patents on invention. 5Doctor of Science and 17PhD theses were defended on the materials of this work.