Application of umbilical cord blood in surgery for critical congenital heart defects in the first hours of life

Work number - P 47 FILED

Authors:

Yemets I.N., Rudenko N.M., Zhovnir V.A., Cohen G.A., Lewin M.B.

Submitted from state institution «Scientific-Practical Medical Centre of Pediatric Cardiology and Cardiac Surgery of the Ministry of Health of Ukraine."

In this work a solution is proposed to major scientific and technical problems of surgical treatment of prenatally diagnosed complex critical congenital heart disease (CHD) in the first hours of newborns life using autologous umbilical cord blood (AUCB) for cardiopulmonary bypass.

Introduced for the first time in the world is a program of emergency surgical care for newborns with critical congenital heart defects in the first hours of life using autologous umbilical cord blood. AUCB has better effect on adaptive and repair processes during the postoperative period compared to homologous donor blood. Hsp60 levels in blood serum of newborns with critical CHD are used as a safety marker of cord blood during complex surgical treatment. These studies are unparalleled in the world.

Perinatal tactics for pregnancy management in critical congenital heart disease of fetus was developed and implemented. About 80% of pregnant women diagnosed with critical CHD of fetus delivered in Kyiv. This allowed to reduce the number of emergency transports of critically ill newborns from distant regions of Ukraine and to increase the number of cardiac surgeries in neonates simultaneously decreasing postoperative mortality.

The economic effect from method's implementation: treatment costs in the first hours of life using AUCB are reduced by 50.2% comparing with patients operated following standard method.

World-class level of research was recognised at international forums in the USA, Europe, Thailand, India, Turkey, Korea, and Russia.

Research results are published in 154 scientific work: 2textbooks and 152 articles,including 46 - abroad. Novelty and competitiveness are reserved by 10 patents and two certificates of copyright registration. There were 3 dissertations defended.